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Latanoprost is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressureIOPby increasing the outflow of aqueous humorStudies in animals and man suggest that the main mechanism of action is increased uveoscleral outflowElevated IOP represents a major risk factor for glaucomatous field lossThe higher the level of IOPthe greater the likelihood of optic nerve damage and visual field loss.

Latanoprost was not mutagenic in bacteriain mouse lymphomaor in mouse micronucleus testsChromosome aberrations were observed in vitro with human lymphocytesAdditional in vitro and in vivo studies on unscheduled DNA synthesis in rats were negative.

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