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Treatment resistance is defined as a lack of satisfactory clinical improvement despite the use of adequate doses of at least two different antipsychotic agentsincluding an atypical antipsychotic agentprescribed for adequate duration.

Do not stop taking clozapine without consulting your doctorSome conditions may become worse when the drug is suddenly stoppedAlsoyou may experience symptoms such as severe sweatingheadachenauseavomitingand diarrheaTo prevent these symptoms while you are stopping treatment with this drugyour doctor may reduce your dose graduallyConsult your doctor or pharmacist for more detailsReport any new or worsening symptoms right away.

Do not stop taking clozapine without consulting your doctorSome conditions may become worse when the drug is suddenly stoppedAlsoyou may experience symptoms such as severe sweatingheadachenauseavomitingand diarrheaTo prevent these symptoms while you are stopping treatment with this drugyour doctor may reduce your dose graduallyConsult your doctor or pharmacist for more detailsReport any new or worsening symptoms right away.

Signs of inflammation in your bodyeasy bruising or bleedingsevere tingling or numbnessmuscle weaknessupper stomach painjaundiceyellowing of the skin or eyeschest painnew or worsening coughtrouble breathing.

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eye clozaril has potent anticholinergic effects and care should be exercised in using this drug in the presence of narrow angle glaucoma.

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