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It works by affecting the body’s response to some nerve impulsesespecially in the heartAs a resultit decreases the heart’s need for blood and oxygen and therefore reduces the amount of work the heart has to doIt also helps the heart to beat more regularly.

If clonidine and a beta blockersuch as metoprolol are coadministeredwithdraw the beta-blocker several days before the gradual withdrawal of clonidine because beta-blockers may exacerbate the rebound hypertension that can follow the withdrawal of clonidineIf replacing clonidine by betablocker therapydelay the introduction of beta-blockers for several days after clonidine administration has stoppedsee WARNINGS AND PRECAUTIONS

Some antihypertensive drugs have smaller blood pressure effectsas monotherapyin black patientsand many antihypertensive drugs have additional approved indications and effectse.gon anginaheart failureor diabetic kidney diseaseThese considerations may guide selection of therapy.

TOPROL-XLlike other beta-blocker medicinestends to decrease blood circulation in the skinfingers and toesIt may make you more sensitive to cold weatherespecially if you have circulation problems.

If you feel a worsening of your condition in the early stages of taking TOPROL-XLtell your doctor immediately.

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