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A single-dosemetformin-furosemide drug interaction study in healthy subjects demonstrated that pharmacokinetic parameters of both compounds were affected by coadministrationFurosemide increased the metformin plasma and blood C max by 22and blood AUC by 15without any significant change in metformin renal clearanceWhen administered with metforminthe C max and AUC of furosemide were 31and 12smallerrespectivelythan when administered aloneand the terminal half-life was decreased by 32without any significant change in furosemide renal clearanceNo information is available about the interaction of metformin and furosemide when coadministered chronically.

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